Sirolimus-induced pulmonary toxicity without recurrence more than 8 years after everolimus replacement in a renal transplant patient with recurrent skin SCC: a case report

Sirolimus-induced pulmonary toxicity without recurrence more than 8 years after everolimus replacement in a renal transplant patient with recurrent skin SCC: a case report

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Abstract Background here Interstitial Pneumonitis (IP) is one of the pulmonary complications associated with mammalian Target of Rapamycin-Inhibitors (mTOR-Is).Sirolimus and everolimus belong to mTOR-Is.According to studies, IP is caused by both.Case presentation This is a case report in a kidney transplant recipient.We want to present a case of IP after 50 months of sirolimus consumption.

Sirolimus was discontinued, and cyclosporine was started.Thirty-seven months later, everolimus was prescribed as an alternative to cyclosporine due to the recurrence of skin Squamous Cell Carcinoma (SCC).Fortunately, no respiratory manifestations were seen after more than 8 years of everolimus consumption.Conclusions In conclusion, in cases with sirolimus-induced IP, discontinuation read more of sirolimus and replacement with everolimus are recommended after resolving clinical symptoms and pulmonary lesions.